Электронный каталог

Статья

Kurakin, S.A.
Lipid Membrane Destabilization Induced by Amyloid-Beta Peptide in the Systems Mimicking Preclinical Alzheimer's Disease / S.A.Kurakin, O.I.Ivankov, T.N.Murugova, D.R.Badreeva, E.B.Dushanov, E.V.Ermakova, A.I.Kuklin, N.Kucerka. – Text: electronic // Natural Science Review. – 2025. – No. 2. – P. 100202. – URL: https://nsr-jinr.ru/index.php/nsr/article/view/30/31. – Bibliogr.: 186.

The amyloid-beta peptide (Aβpeptide) is proposed to play a central role in the onset of Alzheimer’sdisease (AD). The pathology is associated with the fast accumulation of neurotoxic amyloid aggregatesin brain tissues, though the fundamentals of the disease’s progression remain unsolved. It is noted thatthe preclinical stage of AD may play a crucial role in its further irreversible development. Namely,interactions between lipid membranes and Aβ-peptide molecules incorporated therein at relatively lowconcentrations should be under a close attention. In this review, we discuss recent works devoted tostudying the lipid–peptide interactions with a specific focus on the lipid membrane reorganizationscaused by Aβ(25–35) peptide in the preclinical AD mimicking conditions. The interactions observedare believed to be important in understanding the mechanisms of the Aβ-peptide destructive effects onlipid membranes and the corresponding onset of the disease. The methods of applied nuclear physicshave proven remarkably relevant in such research. The scattering methods provided instrumentalinformation on a level of supramolecular assemblies, while spectrometry allowed obtaining informationon the molecular level. Finally, molecular dynamics simulations provided details unachievable byexperimental approaches, though the validation role of the latter cannot be undermined. Altogether,the recent advances in research results prove these complementary approaches the most appropriatefor tackling the complex issues of biomembrane interactions.



ОИЯИ = ОИЯИ (JINR)2025
Спец.(статьи,препринты) = 28.0 - Биология$
Спец.(статьи,препринты) = С 17 к - Расчеты по молекулярной динамике. Численное моделирование физических задач