Электронный каталог

Статья

Kurakina, E.S.
Separation of &sup(44m)Sc/&sup(44g)Sc Nuclear Isomers Based on After-Effects / E.S.Kurakina, J.Khushvaktov, D.Filosofov, [a.o.] // Inorganic Chemistry [Electronic resource]. – 2023. – Vol. 62, No. 50. – P. 20646-20654. – URL: https://doi.org/10.1021/acs.inorgchem.3c01495.

44gSc presents a particular interest for application in nuclear medicine for positron emission tomography (PET) due to its favorable nuclear decay properties (t1/2 = 3.97 h, Emax = 1.47 MeV, branching ratio 94.3% β+). Its nuclear isomer 44mSc (t1/2 = 58.61 h) decays by isomeric transition (IT) into 44gSc, accompanied by ≈12% of conversion electron emission, which can cause a partial release of the daughter 44gSc from the chelate complex. A 13 MeV cyclotron at TRIUMF was used to produce both 44mSc and 44gSc via the natCa(p,n)44m,gSc reaction. A 44mSc/44gSc generator was designed by using a Strata C-18E cartridge. After several tested systems, a successful separation method was developed using DOTATOC as a chelator, a Strata C-18E cartridge as a generator column, and an elution solution of 0.1 M NH4-α-HIB. The yield of the generator with the daughter 44gSc release was equal to 9.8 ± 1.0% (or ≈80% per portion of conversion). This result shows the important role of after-effects in the design of radionuclide generators. Nuclear cross-section calculations were applied using the TALYS code to allow for the determination of the most promising alternative routes for 44mSc production, which will enable the development of a full-scale 44mSc/44gSc radionuclide generator based on after-effects.



ОИЯИ = ОИЯИ (JINR)2023
Спец.(статьи,препринты) = С 341.2в - Уровни ядер
Спец.(статьи,препринты) = С 350 - Приложения методов ядерной физики в смежных областях