Электронный каталог

Книга (аналит. описание)

Kurakina, E.
Post-Decay Processes in Radiopharmaceutical Precursors Studied Via Nuclear Spectroscopy / E.Kurakina, V.Radchenko, D.Karaivanov, A.Velichkov, E.Magomedbekov, D.Filosofov // The 2nd International African Symposium on Exotic Nuclei IASEN2024, Cape Town, 09 - 13 December 2024 : Book of Abstracts [Electronic resource]. – Cape Town, 2024. – P. 18-19. – URL: http://inis.jinr.ru/sl/NTBLIB/IASEN-2024-P18.pdf.

Modern radiopharmaceuticals are actively used for diagnostics and therapy in nuclear medicine. The concept of a modern radiopharmaceutical allows incorporating radionuclides with similar properties to the same precursors. Radiopharmaceutical precursor and its stability play a major role in applicability of such a drug. Post-decay processes, namely Auger and conversion electron emissions, may cause a change in local environment which can lead to release of the daughter from the radiopharmaceutical and, therefore, difficulties in its application. The present work highlights several medically relevant isotopes – 44Sc and 111In coupled with the chelators. 44Sc (t1/2 = 4.04 h) is a radiometal with favourable decay properties for positron emission tomography (PET) and 111In (t1/2 = 2.8 d) is already in the clinical use for diagnostics via single photon emission computed tomography (SPECT). Moreover, 111In is a well-established probe nucleus in perturbed angular correlation of γ-γ rays (PAC), which allows for the study of hyperfine interactions and, hence, is a unique technique when analysing post-decay processes in radiopharmaceutical precursors. Also, the study demonstrates feasibility of 44mSc/44gSc radionuclide generator induced by post-decay processes. The radionuclide generator yield was measured by *g-spectroscopy and equals to 9.8±1.0%. This result indicates the influence of post-decay processes on the initial chelate complexes for the elements with medium Z and significantly changes the overall trend.



Спец.(статьи,препринты) = С 350 - Приложения методов ядерной физики в смежных областях
Спец.(статьи,препринты) = С 349 д - Биологическое действие излучений$
ОИЯИ = ОИЯИ (JINR)2024