Электронный каталог

Статья

Vlasova, A.D.
Intracellular Microbial Rhodopsin-Based Optogenetics to Control Metabolism and Cell Signaling / A.D.Vlasova, A.V.Vlasov, V.I.Borshchevskiy, [a.o.] // Chemical Society Reviews [Electronic resource]. – 2024. – Vol. 53, N. 7. – P. 3327-3349. – URL: https://pubs.rsc.org/en/content/articlelanding/2024/cs/d3cs00699a.

Microbial rhodopsin (MRs) ion channels and pumps have become invaluable optogenetic tools for neuroscience as well as biomedical applications. Recently, MR-optogenetics expanded towards subcellular organelles opening principally new opportunities in optogenetic control of intracellular metabolism and signaling via precise manipulations of organelle ion gradients using light. This new optogenetic field expands the opportunities for basic and medical studies of cancer, cardiovascular, and metabolic disorders, providing more detailed and accurate control of cell physiology. This review summarizes recent advances in studies of the cellular metabolic processes and signaling mediated by optogenetic tools targeting mitochondria, endoplasmic reticulum (ER), lysosomes, and synaptic vesicles. Finally, we discuss perspectives of such an optogenetic approach in both fundamental and applied research.



ОИЯИ = ОИЯИ (JINR)2024
Спец.(статьи,препринты) = 28.0 - Биология$
Спец.(статьи,препринты) = С 44 - Аналитическая химия
Бюллетени = 32/024