Электронный каталог

Статья

Ivankov, O.
Anionic Lipids Modulate Little the Reorganization Effect of Amyloid-Beta Peptides on Membranes / O.Ivankov, D.R.Badreeva, E.V.Ermakova, T.Kondela, T.N.Murugova, N.Kucerka // General Physiology and Biophysics [Electronic resource]. – 2023. – Vol. 42, No. 1. – P. 59-66. – URL: https://doi.org/10.4149/gpb_2022052. – Bibliogr.: p.65-66.

Amyloid-β peptide interactions with model lipid membranes have been studied by means of small angle neutron scattering and molecular dynamics simulations. These interactions had been indicated recently as an origin of the membrane structure reorganizations between spherical small unilamellar vesicles and planar bicelle-like structures. In present work, we investigate the influence of charge on the peptide-triggered morphological changes by introducing the anionic lipid DMPS to the underlying DMPC membrane. Changes to the membrane thickness and the overall membrane structure with and without Aβ25–35 incorporated have been investigated over a wide range of temperatures. Our results document the previously reported morphological reformations between bicelle-like structures present in gel phase and small unilamellar vesicles present in fluid phase to be independent from the charge existence in the system.



ОИЯИ = ОИЯИ (JINR)2023
Спец.(статьи,препринты) = С 342 г2 - Взаимодействие нейтронов с конденсированными средами. Магнитные взаимодействия
Спец.(статьи,препринты) = С 44 б - Разделение химических элементов экстракционными и ионообменными методами
Спец.(статьи,препринты) = С 17 к - Расчеты по молекулярной динамике. Численное моделирование физических задач
Бюллетени = 12/024