Электронный каталог

Статья

Naumenko, M.V.
Interaction of the Anticancer Drug Sulforaphane with DMPC Model Lipid Membranes / M.V.Naumenko, O.Yu.Ponomareva, N.A.Drozhzhin, L.I.Savostina, E.F.Ismagilova, Yu.E.Gorshkova // Физика элементарных частиц и атомного ядра. Письма. – 2026. – Т. 23, № 5. – P. 527. – URL: https://www1.jinr.ru/Pepan_letters/panl_2026_5/59_Naumenko_ann.pdf.

The interaction of the anticancer drug sulforaphane with DMPC lipid membranes was studied. Shift of the isothiocyanate vibrational band in the infrared spectra showed the incorporation of sulforaphane molecules into the lipid bilayer. At a lipid/sulforaphane ratio of 50/1, the internal radius and thickness of the lipid bilayer of unilamellar liposomes did not change significantly, as follows from the small-angle X-ray scattering data. An increase in the number of guest molecules (10/1) led to the fusion of liposomes and the formation of multilamellar vesicles.



Спец.(статьи,препринты) = 28.0 - Биология$