Электронный каталог

Статья

Laouameria, A.N.
Evaluation of Daughter Radionuclide Release from the *1*0*3Pb/&sup(103m)Rh in Vivo Generator for Targeted Auger Therapy / A.N.Laouameria, E.S.Kurakina, [a.o.]. – Text : electronic // Pharmaceuticals. – 2026. – Vol. 19, No. 1. – P. 126. – URL: https://doi.org/10.3390/ph19010126. – Bibliogr.: 40.

Background/Objectives: The &sup(103)Pd/&sup(103)mRh in vivo generator represents a promising Auger electron-emitting system, in which both parent and daughter radionuclides emit predominantly Auger electrons with minimal accompanying radiation. This study investigates the release dynamics of daughter radionuclides from the &sup(103)Pd/&sup(103)mRh in vivo generator and evaluates the underlying mechanisms governing bond rupture and daughter retention. Methods: Cyclotron irradiation of rhodium foils was performed in two separate batches, followed by radionuclide separation using conventional wet chemistry and a novel dry distillation technique. The purified &sup(103)Pd radionuclide was used to radiolabel DOTA-TATE, phthalocyanine-TATE, and DOTA-TOC chelators. The resulting complexes were immobilized on Strata-X and Strata-C18 solid-phase extraction columns. Scheduled elution experiments were conducted to quantify the release of the &sup(103m)Rh daughter radionuclide. Results: The measured &sup(103m)Rh release rates were 9.8 ± 3.0% and 9.6 ± 2.7% from Strata-X columns with DOTA-TATE and phthalocyanine-TATE, respectively, and 10.5 ± 2.7% and 12.0 ± 0.5% from Strata-X and Strata-C18 columns, respectively, with DOTA-TOC. These values are significantly lower than the ~100% release predicted based on the reported Auger electron yield of 186%. One explanation for this difference could be potential inconsistencies in decay data that may require correction; this needs further investigation. The results further demonstrated that delocalized π-electrons, introduced via phthalocyanine-based chelation, did not mitigate daughter release. Conclusions: The low observed daughter nuclide release represents a favorable characteristic for the future clinical translation of the &sup(103)Pd/&sup(103)mRh Auger emitter pair. The findings support the conclusion that Auger electron cascades, rather than nuclear recoil energy, dominate bond rupture processes.



ОИЯИ = ОИЯИ (JINR)2026
Спец.(статьи,препринты) = С 350 - Приложения методов ядерной физики в смежных областях
Спец.(статьи,препринты) = С 413 г - Химические эффекты ядерных превращений. Химические формы стабилизации продуктов ядерных реакций. Радиационная химия