Электронный каталог

Статья

Filosofov, D.
Potent Candidates for Targeted Alpha Therapy (TAT) / D.Filosofov, A.Baimukhanova, J.Khushvaktov, E.Kurakina, V.Radchenko. – Text : electronic // Nuclear Medicine and Biology. – 2025. – Vol. 146-147. – P. 109027. – URL: https://doi.org/10.1016/j.nucmedbio.2025.109027. – Bibliogr.: 209.

Targeted Alpha Therapy (TAT) holds significant promise as a localized treatment for cancer. Encouraging clinical results from using peptides and antibodies labeled with alpha emitters to treat patients with metastatic cancers, particularly those who have not responded to other therapies, provide compelling evidence of TAT's potential. To fully realize the benefits of TAT, it is essential to carefully select appropriate radionuclides and targeting delivery systems to maximize therapeutic efficacy while minimizing nonspecific toxicity to healthy tissues. This review explores key radiochemical, radiopharmaceutical, and radiation-biological considerations for current TAT candidates, and proposes additional potential candidates, establishing a foundation and criteria for the ongoing development of TAT radiopharmaceuticals



Спец.(статьи,препринты) = С 350 - Приложения методов ядерной физики в смежных областях
Спец.(статьи,препринты) = С 349 д - Биологическое действие излучений$
ОИЯИ = ОИЯИ (JINR)2025