Электронный каталог

Статья

Kurakina, E.S.
Production and Purification of Radiolabeling-Ready &sup(132/135)La from the Irradiation of Metallic &sup(nat)Ba Targets with Low Energy Protons / E.S.Kurakina, J.Khushvaktov, N.T.Temerbulatova, N.A.Mirzayev, D.V.Filosofov, [a.o.]. – Text : electronic // Nuclear Medicine and Biology. – 2025. – Vol. 144-145. – P. 108994. – URL: https://doi.org/10.1016/j.nucmedbio.2025.108994. – Bibliogr.: 24.

Introduction: Radiolanthanides &sup(132)La and &sup(135)La form a promising chemically matched theranostic pair. With a half-life of 18.95 h, &sup(135)La acts as the therapeutic isotope as it releases approximately 11 Auger electrons per decay, making it compatible with targeted Auger electron therapy (TAET), whereas &sup(132)La with half-life of 4.58 h undergoes positron emission making it compatible with imaging via positron emission tomography (PET). Methods : &sup(132/135)La were produced via irradiation of natural barium targets (99.9 %) with 12.8 MeV protons. A two-step separation scheme using extraction chromatographic resin TK200 (50–100 μm) and cation exchange resin Dowex 50Wx4 (200–400 mesh) was designed. Inductively coupled plasma mass spectrometry (ICP-MS) was used to quantify non-radioactive impurities in each fraction of the separation method. The distribution coefficients of La&sup(3+) in HNO&sub(3) on the TK200 resin and on both Dowex 50Wx8 (200–400 mesh) and Dowex 50Wx4 resins in ammonium α-hydroxyisobutyrate (pH 4.8) were determined, respectively. Results : This novel separation scheme allowed for reliable separation of [&sup(132/135)La]La&sup(3+) from the Ba&sup(2+) target material, resulting in a high radiochemical yield of 98.3 ± 2.1 % (n = 3) with the final elute being directly compatible with subsequent radiolabeling due to the use of ammonium α-hydroxyisobutyrate to eliminate steps in the radiopharmaceutical synthetic process.



Спец.(статьи,препринты) = С 350 - Приложения методов ядерной физики в смежных областях
Спец.(статьи,препринты) = С 349.1 - Действие излучения на материалы$
Спец.(статьи,препринты) = С 413 - Радиохимия
ОИЯИ = ОИЯИ (JINR)2025
Бюллетени = 30/025