Электронный каталог

Статья

Zamulaeva, I.A.
Effects of Fractionated Proton Irradiation in Combination with 1-*b-D-Arabinofuranosylcytosine on B16 Murine Melanoma In Vivo : Abstract / I.A.Zamulaeva, O.N.Matchuk, A.V.Boreyko, V.N.Chausov, E.A.Krasavin, [et al.] // Физика элементарных частиц и атомного ядра. Письма. – 2024. – Т. 21, № 6. – P. 1128. – URL: http://www1.jinr.ru/Pepan_letters/panl_2024_6/14_Zamulaeva_ann.pdf.

This study is a search for means of sensitization of malignant tumors to proton radiation among DNA damage repair inhibitors. It has been found that in the presence of 1-*b-Darabinofuranosylcytosine (AraC), five weekly proton irradiations at a total focal dose of 50 Gy lead to a more pronounced inhibition of B16 murine melanoma growth than the same irradiation without AraC (p < 0.05). This effect, associated with a decrease in the proliferative activity of cells in the general population and a decrease in the number of cancer stem cells specifically in the AraC + protons group, is promising for further improvement of proton radiotherapy.



Спец.(статьи,препринты) = С 349 д - Биологическое действие излучений$
ОИЯИ = ОИЯИ (JINR)2024